Relaxin family peptides in the male reproductive system--a critical appraisal
نویسندگان
چکیده
منابع مشابه
Relaxin in the male reproductive system
Relaxin (RLN) belongs to a family of hormones structurally related to insulin and presents a broad spectrum of actions. Humans have three forms of RLN, encoded by three different genes (RLN1, RLN2 and RLN3), but nonprimate vertebrates have only two forms of relaxin (RLN1 and RLN3). RLN1 of these animals is encoded by Rln1, orthologous to the human RLN2 gene, and both genes, Rln1 and human RLN2,...
متن کاملRelaxin family peptides and their receptors.
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a vasodilator and cardiac stimulant in the cardiovascular system, and as an antifibrotic agent. Insulin-like peptide-3 (INSL3) has clearly defined specialist roles in male and female reproduction, relaxi...
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Evidence-based medicine has become the golden standard of good medical practice. I analysed meta-analyses and systematic reviews, the cornerstones of evidence-based medicine, pertaining to two important problems in in vitro fertilization: failed implantation and poor ovarian response to ovarian stimulation. Numerous interventions and procedures have been tried to facilitate implantation and to ...
متن کاملMilk-borne relaxin and reproductive system development.
A window of opportunity for maternal programming of neonatal development is open in the first few days of life as a consequence of nursing. Colostrum (first milk) supports neonatal development by providing a conduit for delivery of milk-borne bioactive factors, exemplified by relaxin, from mother to offspring as proposed in the lactocrine hypothesis. Relaxin, a prototypical milk-borne bioactive...
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BACKGROUND Prediction models have been developed in reproductive medicine to help assess the chances of a treatment-(in)dependent pregnancy. Careful evaluation is needed before these models can be implemented in clinical practice. METHODS We systematically searched the literature for papers reporting prediction models in reproductive medicine for three strategies: expectant management, intrau...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2010
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gaq086